History & Society What epidemic killed the most people? June 1, 2026 by Myaya | Leave a Comment The epidemic that has historically killed the most people is the Black Death, a devastating bubonic plague pandemic that swept across Eurasia and North Africa in the mid-14th century, claiming an estimated 75 to 200 million lives. This catastrophic event profoundly reshaped societies and economies worldwide. Unveiling the Deadliest Epidemics in Human History Throughout history, […] Read more ยป